Comparison of Alternative Splicing Landscapes Revealed by Long-Read Sequencing in Hepatocyte-Derived HepG2 and Huh7 Cultured Cells and Human Liver Tissue

Comparison of Alternative Splicing Landscapes Revealed by Long-Read Sequencing in Hepatocyte-Derived HepG2 and Huh7 Cultured Cells and Human Liver Tissue

The long-read RNA sequencing developed by Oxford Nanopore Technologies provides a direct quantification of transcript isoforms, thereby making it possible to present alternative splicing (AS) profiles as arrays of single splice variants with different abundances. Additionally, AS profiles can be pre...

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Bibliographic Details
Main Authors: Anna Kozlova, Elizaveta Sarygina, Kseniia Deinichenko, Sergey Radko, Konstantin Ptitsyn, Svetlana Khmeleva, Leonid Kurbatov, Pavel Spirin, Vladimir Prassolov, Ekaterina Ilgisonis, Andrey Lisitsa, Elena Ponomarenko
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biology
Subjects:
transcriptome
long-read sequencing
alternative splicing
degree of alternative splicing
splice variants abundance
human liver tissue
Online Access:https://www.mdpi.com/2079-7737/12/12/1494

Internet

https://www.mdpi.com/2079-7737/12/12/1494

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