Co-expression of Skp and FkpA chaperones improves cell viability and alters the global expression of stress response genes during scFvD1.3 production
<p>Abstract</p> <p>Background</p> <p>The overexpression of scFv antibody fragments in the periplasmic space of <it>Escherichia coli </it>frequently results in extensive protein misfolding and loss of cell viability. Although protein folding factors such as S...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2010-04-01
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| Series: | Microbial Cell Factories |
| Online Access: | http://www.microbialcellfactories.com/content/9/1/22 |