The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1

The E3 Ubiquitin Protein Ligase LINCR Amplifies the TLR-Mediated Signals through Direct Degradation of MKP1

Toll-like receptors (TLRs) induce innate immune responses through activation of intracellular signaling pathways, such as MAP kinase and NF-κB signaling pathways, and play an important role in host defense against bacterial or viral infections. Meanwhile, excessive activation of TLR signaling leads...

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Bibliographic Details
Main Authors: Takumi Yokosawa, Sayoko Miyagawa, Wakana Suzuki, Yuki Nada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa
Format: Article
Language:English
Published: MDPI AG 2024-04-01
Series:Cells
Subjects:
Toll-like receptors (TLRs)
MAP kinases
MAPK phosphatase-1 (MKP1)
the E3 ubiquitin ligase LINCR
ubiquitination
Online Access:https://www.mdpi.com/2073-4409/13/8/687

Internet

https://www.mdpi.com/2073-4409/13/8/687

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