In Vivo Acute on Chronic Ethanol Effects in Liver: A Mouse Model Exhibiting Exacerbated Injury, Altered Metabolic and Epigenetic Responses

Chronic alcoholics who also binge drink (i.e., acute on chronic) are prone to an exacerbated liver injury but its mechanism is not understood. We therefore investigated the in vivo effects of chronic and binge ethanol ingestion and compared to chronic ethanol followed by three repeat binge ethanol o...

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Bibliographic Details
Main Authors: Shivendra D. Shukla, Annayya R. Aroor, Ricardo Restrepo, Kusum K. Kharbanda, Jamal A. Ibdah
Format: Article
Language:English
Published: MDPI AG 2015-11-01
Series:Biomolecules
Subjects:
Online Access:http://www.mdpi.com/2218-273X/5/4/3280