Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer

Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer

Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug de...

Full description

Bibliographic Details
Main Authors: Annamaria Antona, Marco Varalda, Konkonika Roy, Francesco Favero, Eleonora Mazzucco, Miriam Zuccalà, Giovanni Leo, Giulia Soggia, Valentina Bettio, Martina Tosi, Miriam Gaggianesi, Beatrice Riva, Simone Reano, Armando Genazzani, Marcello Manfredi, Giorgio Stassi, Davide Corà, Sandra D’Alfonso, Daniela Capello
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Cancers
Subjects:
repurposing
phospholipase C
colorectal cancer
endoplasmic reticulum stress
intracellular calcium
lipid metabolism
Online Access:https://www.mdpi.com/2072-6694/14/3/776

Internet

https://www.mdpi.com/2072-6694/14/3/776

Similar Items