A Simple Model to Study Mosaic Gene Expression in 3D Endothelial Spheroids

Aims: The goal of this study was to establish a simple model of 3D endothelial spheroids with mosaic gene expression using adeno-associated virus (AAV) transduction, with a future aim being to study the activity of post-zygotic mutations common to vascular malformations. Methods: In this study, 96-w...

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Bibliographic Details
Main Authors: Lucinda S. McRobb, Vivienne S. Lee, Fahimeh Faqihi, Marcus A. Stoodley
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
Online Access:https://www.mdpi.com/2308-3425/11/10/305