Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

Objective: Adipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose tissue lipogenesis to fat mass, especially in the setting of high-fat feeding, is considered minor. Here we investigated the effect of adipose-specific inactivation of the perox...

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Bibliographic Details
Main Authors: Brian Kleiboeker, Anyuan He, Min Tan, Dongliang Lu, Donghua Hu, Xuejing Liu, Parniyan Goodarzi, Fong-Fu Hsu, Babak Razani, Clay F. Semenkovich, Irfan J. Lodhi
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:Molecular Metabolism
Subjects:
Adipose tissue
Cholesterol
De novo lipogenesis
Diabetes
Plasmalogen
Liver X receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824000449

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http://www.sciencedirect.com/science/article/pii/S2212877824000449

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