Unconjugated Multi-Epitope Peptides Adjuvanted with ALFQ Induce Durable and Broadly Reactive Antibodies to Human and Avian Influenza Viruses

Unconjugated Multi-Epitope Peptides Adjuvanted with ALFQ Induce Durable and Broadly Reactive Antibodies to Human and Avian Influenza Viruses

An unconjugated composite peptide vaccine targeting multiple conserved influenza epitopes from hemagglutinin, neuraminidase, and matrix protein and formulated with a safe and highly potent adjuvant, Army Liposome formulation (ALFQ), generated broad and durable immune responses in outbred mice. The a...

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Bibliographic Details
Main Authors: Nimisha Rikhi, Clara J. Sei, Mangala Rao, Richard F. Schuman, Kellie A. Kroscher, Gary R. Matyas, Kevin Muema, Camille Lange, Aba Assiaw-Dufu, Elizabeth Hussin, Ousman Jobe, Carl R. Alving, Gerald W. Fischer
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Vaccines
Subjects:
peptides
influenza
ALFQ
liposomes
QS21 (also known as QS-21)
universal vaccine
Online Access:https://www.mdpi.com/2076-393X/11/9/1468

Internet

https://www.mdpi.com/2076-393X/11/9/1468

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