Simultaneous Expression of Th1- and Treg-Associated Chemokine Genes and CD4<sup>+</sup>, CD8<sup>+</sup>, and Foxp3<sup>+</sup> Cells in the Premalignant Lesions of 4NQO-Induced Mouse Tongue Tumorigenesis

Simultaneous Expression of Th1- and Treg-Associated Chemokine Genes and CD4<sup>+</sup>, CD8<sup>+</sup>, and Foxp3<sup>+</sup> Cells in the Premalignant Lesions of 4NQO-Induced Mouse Tongue Tumorigenesis

Chemokines and cytokines in the tumor microenvironment influence immune cell infiltration and activation. To elucidate their role in immune cell recruitment during oral cancer development, we generated a mouse tongue cancer model using the carcinogen 4-nitroquinoline 1-oxide (4NQO) and investigated...

Full description

Bibliographic Details
Main Authors: Hana Yamaguchi, Miki Hiroi, Kazumasa Mori, Ryosuke Ushio, Ari Matsumoto, Nobuharu Yamamoto, Jun Shimada, Yoshihiro Ohmori
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
chemokine
Th1
Th2
Treg
Foxp3
gene expression
Online Access:https://www.mdpi.com/2072-6694/13/8/1835

Internet

https://www.mdpi.com/2072-6694/13/8/1835

Similar Items