n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine

n-Tuples on Scaffold Diversity Inspired by Drug Hybridisation to Enhance Drugability: Application to Cytarabine

A mathematical concept, n-tuples are originally applied to medicinal chemistry, especially with the creation of scaffold diversity inspired by the hybridisation of different commercial drugs with cytarabine, a synthetic arabinonucleoside derived from two marine natural products, spongouridine and sp...

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Bibliographic Details
Main Authors: Miguel García-Castro, David Fuentes-Rios, J. Manuel López-Romero, Antonio Romero, Federico Moya-Utrera, Amelia Díaz-Morilla, Francisco Sarabia
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Marine Drugs
Subjects:
scaffold diversity
dual drugs
chemical space
arabinonucleosides
n-duples
Online Access:https://www.mdpi.com/1660-3397/21/12/637

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https://www.mdpi.com/1660-3397/21/12/637

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