Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Perfluorooctane sulfonate (PFOS) and its alternative 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFESA) are ubiquitous in various environmental and human samples. They have been reported to have hepatotoxicity effects, but the potential mechanisms remain unclear. Herein, we integrated me...

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Bibliographic Details
Main Authors: Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Ecotoxicology and Environmental Safety
Subjects:
6:2 Cl-PFESA
PFOS
Proteomics
Metabolomics
Primary human hepatocytes
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651322012015

Internet

http://www.sciencedirect.com/science/article/pii/S0147651322012015

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