Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats

Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats

In amyotrophic lateral sclerosis (ALS), the exogenous temporal triggers that result in initial motor neuron death are not understood. Overactivation and consequent accelerated loss of vulnerable motor neurons is one theory of disease initiation. The vulnerability of motor neurons in response to chro...

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Bibliographic Details
Main Authors: Angelo C. Lepore, Christopher Tolmie, John O'Donnell, Megan C. Wright, Christine Dejea, Britta Rauck, Ahmet Hoke, Anthony R. Ignagni, Raymond P. Onders, Nicholas J. Maragakis
Format: Article
Language:English
Published: Elsevier 2010-09-01
Series:Neurobiology of Disease
Subjects:
Motor neuron
Neurodegeneration
ALS
Amyotrophic lateral sclerosis
SOD1
Phrenic nerve
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996110000938

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http://www.sciencedirect.com/science/article/pii/S0969996110000938

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