Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling

Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling

Veratrum californicum is a rich source of steroidal alkaloids such as cyclopamine, a known inhibitor of the Hedgehog (Hh) signaling pathway. Here we provide a detailed analysis of the alkaloid composition of V. californicum by plant part through quantitative analysis of cyclopamine, veratramine, mul...

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Bibliographic Details
Main Authors: Matthew W. Turner, Roberto Cruz, Jordan Elwell, John French, Jared Mattos, Owen M. McDougal
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Molecules
Subjects:
hedgehog signaling
Veratrum californicum
cyclopamine
HPLC-MS
Shh-Light II cells
Online Access:http://www.mdpi.com/1420-3049/23/9/2222

Internet

http://www.mdpi.com/1420-3049/23/9/2222

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