Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling

Native V. californicum Alkaloid Combinations Induce Differential Inhibition of Sonic Hedgehog Signaling

Veratrum californicum is a rich source of steroidal alkaloids such as cyclopamine, a known inhibitor of the Hedgehog (Hh) signaling pathway. Here we provide a detailed analysis of the alkaloid composition of V. californicum by plant part through quantitative analysis of cyclopamine, veratramine, mul...

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Bibliographic Details
Main Authors:	Matthew W. Turner, Roberto Cruz, Jordan Elwell, John French, Jared Mattos, Owen M. McDougal
Format:	Article
Language:	English
Published:	MDPI AG 2018-09-01
Series:	Molecules
Subjects:	hedgehog signaling Veratrum californicum cyclopamine HPLC-MS Shh-Light II cells
Online Access:	http://www.mdpi.com/1420-3049/23/9/2222

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