G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis

G protein-coupled receptor 30 activation inhibits ferroptosis and protects chondrocytes against osteoarthritis

Background: Osteoarthritis (OA) is the most common joint disease worldwide, but its cause remains unclear. Oestrogen protects against OA, but its clinical use is limited. G protein-coupled receptor 30 (GPR30) is a receptor that binds oestrogen, and GPR30 treatment has benefitted patients with some d...

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Bibliographic Details
Main Authors: Zhen Zhao, Shun Niu, Jun Chen, Hongtao Zhang, Lizuo Liang, Kui Xu, Chuan Dong, Chang Su, Tao Yan, Yongqiang Zhang, Hua Long, Le Yang, Minggao Zhao
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Journal of Orthopaedic Translation
Subjects:
Ferroptosis
G-coupled protein receptor
Joints
Oestrogen
Osteoarthrosis
Yes-associated protein 1
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X23001043

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http://www.sciencedirect.com/science/article/pii/S2214031X23001043

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