Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer

Chromatin regulation at the intersection of estrogen receptor and PI3K pathways in breast cancer

Estrogen Receptor (ER) and the phosphoinositide 3-kinase (PI3K) pathways participate in regulatory crosstalk in breast cancer. We identified that chromatin regulation is at the intersection of oncogenic PI3K and ER. The PI3K effectors AKT, also known as protein kinase B (PKB), and SGK (serum/glucoco...

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Bibliographic Details
Main Authors: Pau Castel, Eneda Toska
Format: Article
Language:English
Published: Taylor & Francis Group 2019-11-01
Series:Molecular & Cellular Oncology
Subjects:
pi3k pathway
breast cancer
estrogen receptor
kmt2d
chromatin regulation
pi3k inhibitors
therapy resistance
akt1
sgk1
Online Access:http://dx.doi.org/10.1080/23723556.2019.1625620

Internet

http://dx.doi.org/10.1080/23723556.2019.1625620

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