Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition

Transcription Factor E2F1 Knockout Promotes Mice White Adipose Tissue Browning Through Autophagy Inhibition

Obesity is associated with energy metabolic disturbance and is caused by long-term excessive energy storage in white adipose tissue (WAT). The WAT browning potentially reduces excessive energy accumulation, contributing an attractive target to combat obesity. As a pivotal regulator of cell growth, t...

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Bibliographic Details
Main Authors: Mingchen Xiong, Weijie Hu, Yufang Tan, Honghao Yu, Qi Zhang, Chongru Zhao, Yi Yi, Yichen Wang, Yiping Wu, Min Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Physiology
Subjects:
E2F1 transcription factor
obesity
white adipose tissue (WAT)
browning
autophagy
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.748040/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.748040/full

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