Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

Abstract Background Synucleinopathies of the aging population are an heterogeneous group of neurological disorders that includes Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) and are characterized by the progressive accumulation of α-synuclein in neuronal and glial cells. Toll-like re...

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Bibliographic Details
Main Authors: Changyoun Kim, Brian Spencer, Edward Rockenstein, Hodaka Yamakado, Michael Mante, Anthony Adame, Jerel Adam Fields, Deborah Masliah, Michiyo Iba, He-Jin Lee, Robert A. Rissman, Seung-Jae Lee, Eliezer Masliah
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Molecular Neurodegeneration
Subjects:
Immunotherapy
α-synuclein
Toll-like receptor 2
Transmission
Neuroinflammation
Neurodegeneration
Online Access:http://link.springer.com/article/10.1186/s13024-018-0276-2

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http://link.springer.com/article/10.1186/s13024-018-0276-2

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