Herpes Simplex Virus-type1 (HSV-1) Impairs DNA Repair in Cortical Neurons

Herpes Simplex Virus-type1 (HSV-1) Impairs DNA Repair in Cortical Neurons

Several findings suggest that HSV-1 infection plays a role in the neurodegenerative processes that characterize Alzheimer’s disease, but the underlying mechanisms have yet to be fully elucidated. Here we show that HSV-1 productive infection in cortical neurons causes the accumulation of DNA lesions...

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Bibliographic Details
Main Authors: Giovanna De Chiara, Mauro Racaniello, Cristiana Mollinari, Maria Elena Marcocci, Giorgia Aversa, Alessio Cardinale, Anna Giovanetti, Enrico Garaci, Anna Teresa Palamara, Daniela Merlo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-10-01
Series:Frontiers in Aging Neuroscience
Subjects:
DNA Damage
Alzheimer's disease
HSV-1
KU80
DSBs
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00242/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2016.00242/full

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