Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells.

Antitumor effects of chloroquine/hydroxychloroquine mediated by inhibition of the NF-κB signaling pathway through abrogation of autophagic p47 degradation in adult T-cell leukemia/lymphoma cells.

Adult T-cell leukemia/lymphoma (ATLL) originates from human T-cell leukemia virus type 1 (HTLV-1) infection due to the activation of the nuclear factor-κB (NF-κB) signaling pathway to maintain proliferation and survival. An important mechanism of the activated NF-κB signaling pathway in ATLL is the...

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Bibliographic Details
Main Authors: Yanuar Rahmat Fauzi, Shingo Nakahata, Syahrul Chilmi, Tomonaga Ichikawa, Phawut Nueangphuet, Ryoji Yamaguchi, Tatsufumi Nakamura, Kazuya Shimoda, Kazuhiro Morishita
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0256320

Internet

https://doi.org/10.1371/journal.pone.0256320

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