Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus

Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus

IntroductionThe innate immune system serves the crucial first line of defense against a wide variety of potential threats, during which the production of pro-inflammatory cytokines IFN-I and TNFα are key. This astonishing power to fight invaders, however, comes at the cost of risking IFN-I-related p...

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Bibliographic Details
Main Authors: Laura C. Van Eyndhoven, Eleni Chouri, Catarina I. Matos, Aridaman Pandit, Timothy R. D. J. Radstake, Jasper C. A. Broen, Abhyudai Singh, Jurjen Tel
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Immunology
Subjects:
type I interferon
plasmacytoid dendritic cells
systemic lupus erythematosus
heterogeneity
droplet-based microfluidics
ODE modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322814/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322814/full

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