Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus

Unraveling IFN-I response dynamics and TNF crosstalk in the pathophysiology of systemic lupus erythematosus

IntroductionThe innate immune system serves the crucial first line of defense against a wide variety of potential threats, during which the production of pro-inflammatory cytokines IFN-I and TNFα are key. This astonishing power to fight invaders, however, comes at the cost of risking IFN-I-related p...

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Bibliographic Details
Main Authors:	Laura C. Van Eyndhoven, Eleni Chouri, Catarina I. Matos, Aridaman Pandit, Timothy R. D. J. Radstake, Jasper C. A. Broen, Abhyudai Singh, Jurjen Tel
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2024-03-01
Series:	Frontiers in Immunology
Subjects:	type I interferon plasmacytoid dendritic cells systemic lupus erythematosus heterogeneity droplet-based microfluidics ODE modeling
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1322814/full

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