Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits

Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits

Introduction: Genome editing by CRISPR-Cas9 approaches offers promise for introducing or correcting disease-associated mutations for research and clinical applications. Nonhuman primates are physiologically closer to humans than other laboratory animal models, providing ideal candidates for introduc...

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Bibliographic Details
Main Authors: Jenna Kropp Schmidt, Yun Hee Kim, Nick Strelchenko, Sarah R. Gierczic, Derek Pavelec, Thaddeus G. Golos, Igor I. Slukvin
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Genome Editing
Subjects:
CRISPR- Cas9
whole genome sequencing (WGS)
embryo
macaque
CCR5
Online Access:https://www.frontiersin.org/articles/10.3389/fgeed.2022.1031275/full

Internet

https://www.frontiersin.org/articles/10.3389/fgeed.2022.1031275/full

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