Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults

Tetrodotoxin (TTX) is a highly specific voltage-gated sodium channel (VGSC) blocker in clinical evaluation as a peripheral-acting analgesic for chronic pain. This study presents the first published results of the safety including cardiac liability of TTX at therapeutic-relevant concentrations in twe...

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Bibliographic Details
Main Authors: Mojgan Kavoosi, Terry E. O’Reilly, Mehran Kavoosi, Peng Chai, Caroline Engel, Walter Korz, Christopher C. Gallen, Robert M. Lester
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Toxins
Subjects:
tetrodotoxin
pain
analgesic
QT interval
ECG
voltage-gated sodium channels
Online Access:https://www.mdpi.com/2072-6651/12/8/511

Internet

https://www.mdpi.com/2072-6651/12/8/511

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