Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions

Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions

The three members (GADD45α, GADD45β, and GADD45γ) of the growth arrest and DNA damage-inducible 45 (GADD45) protein family are involved in a myriad of diversified cellular functions. With the aim of unravelling analogies and differences, we performed comparative biochemical and biophysical analyses...

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Bibliographic Details
Main Authors: Giovanni Smaldone, Daniela Caruso, Annamaria Sandomenico, Emanuela Iaccarino, Annalia Focà, Alessia Ruggiero, Menotti Ruvo, Luigi Vitagliano
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
protein aggregation
amyloid-like toxicity
structure-stability relationships
Online Access:https://www.mdpi.com/1422-0067/22/19/10700

Internet

https://www.mdpi.com/1422-0067/22/19/10700

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