Obesity induced gut dysbiosis contributes to disease severity in an animal model of multiple sclerosis

BackgroundMultiple sclerosis (MS) is an inflammatory and demyelinating disease of the CNS. The etiology of MS is complex, and results from the interaction of multiple environmental and genetic factors. Although human leukocyte antigen-HLA alleles such as HLA-DR2 and –DR3 are considered the strongest...

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Bibliographic Details
Main Authors: Shailesh K. Shahi, Sudeep Ghimire, Peter Lehman, Ashutosh K. Mangalam
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.966417/full