ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms

ATR Inhibition Potentiates PARP Inhibitor Cytotoxicity in High Risk Neuroblastoma Cell Lines by Multiple Mechanisms

<i>Background:</i> High risk neuroblastoma (HR-NB) is one the most difficult childhood cancers to cure. These tumours frequently present with DNA damage response (DDR) defects including loss or mutation of key DDR genes, oncogene-induced replication stress (RS) and cell cycle checkpoint...

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Bibliographic Details
Main Authors: Harriet E. D. Southgate, Lindi Chen, Deborah A. Tweddle, Nicola J. Curtin
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cancers
Subjects:
poly (ADP-ribose) polymerase inhibitors (PARPi)
ataxia telangiectasia and Rad3 related inhibitors (ATRi)
replication stress
cell cycle checkpoints
Online Access:https://www.mdpi.com/2072-6694/12/5/1095

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https://www.mdpi.com/2072-6694/12/5/1095

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