Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis

Extreme Diversity of IgGs Against Histones, DNA, and Myelin Basic Protein in the Cerebrospinal Fluid and Blood of Patients with Multiple Sclerosis

It was recently shown that IgGs from sera of multiple sclerosis (MS) patients are active in the hydrolysis of DNA and myelin basic protein (MBP). We first analyzed the relative concentration of antibodies against five histones (H1, H2a, H2b, H3, and H4) in the cerebrospinal fluid (CSF) and serum of...

Full description

Bibliographic Details
Main Authors: Irina A. Kostrikina, Valentina N. Buneva, Enrico Granieri, Georgy A. Nevinsky
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Biomolecules
Subjects:
multiple sclerosis
human cerebrospinal fluid
catalytic IgGs
DNase activity
protease activity
extreme diversity of IgGs against auto-antigens
Online Access:https://www.mdpi.com/2218-273X/10/4/630

Internet

https://www.mdpi.com/2218-273X/10/4/630

Similar Items