Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways

Different pancreatic cancer microenvironments convert iPSCs into cancer stem cells exhibiting distinct plasticity with altered gene expression of metabolic pathways

Abstract Background Cancer stem cells (CSCs) are generated under irregular microenvironment in vivo, of which mimic is quite difficult due to the lack of enough information of the factors responsible for cancer initiation. Here, we demonstrated that mouse induced pluripotent cells (miPSCs) reprogram...

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Bibliographic Details
Main Authors: Ghmkin Hassan, Toshiaki Ohara, Said M. Afify, Kazuki Kumon, Maram H. Zahra, Xiaoying Fu, Mohamad Al Kadi, Akimasa Seno, David S. Salomon, Masaharu Seno
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Cancer stem cells
iPSCs
Conversion
Plasticity
Tumorigenesis
Pancreatic cancer microenvironments
Online Access:https://doi.org/10.1186/s13046-021-02167-3

Internet

https://doi.org/10.1186/s13046-021-02167-3

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