KRAS-driven model of Gorham-Stout disease effectively treated with trametinib

KRAS-driven model of Gorham-Stout disease effectively treated with trametinib

Gorham-Stout disease (GSD) is a sporadically occurring lymphatic disorder. Patients with GSD develop ectopic lymphatics in bone, gradually lose bone, and can have life-threatening complications, such as chylothorax. The etiology of GSD is poorly understood, and current treatments for this disease ar...

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Bibliographic Details
Main Authors: Nassim Homayun-Sepehr, Anna L. McCarter, Raphaël Helaers, Christine Galant, Laurence M. Boon, Pascal Brouillard, Miikka Vikkula, Michael T. Dellinger
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-08-01
Series:JCI Insight
Subjects:
Angiogenesis
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.149831

Internet

https://doi.org/10.1172/jci.insight.149831

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