Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins
This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of l...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/9/553 |
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| author | Maria Zimina Olga Babich Alexander Prosekov Stanislav Sukhikh Svetlana Ivanova Margarita Shevchenko Svetlana Noskova |
| author_facet | Maria Zimina Olga Babich Alexander Prosekov Stanislav Sukhikh Svetlana Ivanova Margarita Shevchenko Svetlana Noskova |
| author_sort | Maria Zimina |
| collection | DOAJ |
| description | This paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant. |
| first_indexed | 2024-03-10T16:45:19Z |
| format | Article |
| id | doaj.art-dafa5b3494fd48269949ed972c237ac3 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T16:45:19Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-dafa5b3494fd48269949ed972c237ac32023-11-20T11:43:33ZengMDPI AGAntibiotics2079-63822020-08-019955310.3390/antibiotics9090553Overview of Global Trends in Classification, Methods of Preparation and Application of BacteriocinsMaria Zimina0Olga Babich1Alexander Prosekov2Stanislav Sukhikh3Svetlana Ivanova4Margarita Shevchenko5Svetlana Noskova6Institute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, RussiaInstitute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, RussiaLaboratory of Biocatalysis, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, RussiaInstitute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, RussiaNatural Nutraceutical Biotesting Laboratory, Kemerovo State University, Krasnaya Street 6, 650043 Kemerovo, RussiaInstitute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, RussiaInstitute of Living Systems, Immanuel Kant Baltic Federal University, A. Nevskogo Street 14, 236016 Kaliningrad, RussiaThis paper summarizes information about the division of bacteriocins into classes (Gram-negative bacteria, Gram-positive bacteria, and archaea). Methods for producing bacteriocins have been studied. It is known that bacteriocins, most successfully used today are products of secondary metabolism of lactic acid bacteria. It is established that the main method of bacteriocin research is PCR analysis, which makes it possible to quickly and easily identify the presence of bacteriocin encoding genes. The mechanism of cytotoxic action of bacteriocins has been studied. It is proved that the study of cytotoxic (antitumor) activity in laboratory conditions will lead to the clinical use of bacteriocins for cancer treatment in the near future. It is established that the incorporation of bacteriocins into nanoparticles and targeted delivery to areas of infection may soon become an effective treatment method. The delivery of bacteriocins in a concentrated form, such as encapsulated in nanoparticles, will increase their effectiveness and minimize potential toxic side effects. The analysis of publications on this topic confirmed that diverse research on bacteriocins is relevant.https://www.mdpi.com/2079-6382/9/9/553bacteriocinsantimicrobial actioncytotoxic actionactivity of bacteriocinsprobioticsPCR reactions |
| spellingShingle | Maria Zimina Olga Babich Alexander Prosekov Stanislav Sukhikh Svetlana Ivanova Margarita Shevchenko Svetlana Noskova Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins Antibiotics bacteriocins antimicrobial action cytotoxic action activity of bacteriocins probiotics PCR reactions |
| title | Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins |
| title_full | Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins |
| title_fullStr | Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins |
| title_full_unstemmed | Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins |
| title_short | Overview of Global Trends in Classification, Methods of Preparation and Application of Bacteriocins |
| title_sort | overview of global trends in classification methods of preparation and application of bacteriocins |
| topic | bacteriocins antimicrobial action cytotoxic action activity of bacteriocins probiotics PCR reactions |
| url | https://www.mdpi.com/2079-6382/9/9/553 |
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