Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine

Receptor Transporter Protein 4 (RTP4) in the Hypothalamus Is Involved in the Development of Antinociceptive Tolerance to Morphine

Receptor transporter protein 4 (RTP4), one of the receptor chaperone proteins, contributes to the maturation and membrane trafficking of opioid receptor heteromers consisting of mu (MOPr) and delta (DOPr) opioid receptors (MOPr-DOPr). Although MOPr-DOPr is known to mediate the development of morphin...

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Bibliographic Details
Main Authors: Wakako Fujita, Hitoshi Uchida, Masashi Kawanishi, Yusuke Kuroiwa, Manabu Abe, Kenji Sakimura
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Biomolecules
Subjects:
mu-opioid receptor
receptor transporter protein 4
paraventricular nucleus
tolerance
toll-like receptor 4
mitogen-activated protein kinase
Online Access:https://www.mdpi.com/2218-273X/12/10/1471

Internet

https://www.mdpi.com/2218-273X/12/10/1471

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