Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors

Overcoming resistance of stroma-rich pancreatic cancer with focal adhesion kinase inhibitor combined with G47Δ and immune checkpoint inhibitors

Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease known for its dense tumor stroma. Focal adhesion kinase inhibitor (FAKi), a non-receptor type tyrosine kinase inhibitor, reduces the tumor stroma. G47Δ, a third-generation oncolytic herpes simplex virus type 1, destroys tumor cells selectiv...

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Bibliographic Details
Main Authors: Tomoharu Yamada, Ryosuke Tateishi, Miwako Iwai, Minoru Tanaka, Hideaki Ijichi, Makoto Sano, Kazuhiko Koike, Tomoki Todo
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:Molecular Therapy: Oncolytics
Subjects:
pancreatic ductal adenocarcinoma
G47Δ
oncolytic virus therapy
focal adhesion kinase inhibitor
immune checkpoint inhibitor
teserpaturev
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770522001437

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http://www.sciencedirect.com/science/article/pii/S2372770522001437

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