Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

Neutral sphingomyelinase 2 inhibition attenuates extracellular vesicle release and improves neurobehavioral deficits in murine HIV

People living with HIV (PLH) have significantly higher rates of cognitive impairment (CI) and major depressive disorder (MDD) versus the general population. The enzyme neutral sphingomyelinase 2 (nSMase2) is involved in the biogenesis of ceramide and extracellular vesicles (EVs), both of which are d...

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Bibliographic Details
Main Authors: Xiaolei Zhu, Kristen R. Hollinger, Yiyao Huang, Alejandra Borjabad, Boe-Hyun Kim, Tanina Arab, Ajit G. Thomas, Mohammed Moniruzzaman, Lyndah Lovell, Andrey Turchinovich, Kenneth W. Witwer, David J. Volsky, Norman J. Haughey, Barbara S. Slusher
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Neurobiology of Disease
Subjects:
Neutral sphingomyelinase 2
Depression
Sleep
HIV
Extracellular vesicle
EcoHIV
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122001267

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http://www.sciencedirect.com/science/article/pii/S0969996122001267

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