Metformin enhances the therapeutic effects of extracellular vesicles derived from human periodontal ligament stem cells on periodontitis

Metformin enhances the therapeutic effects of extracellular vesicles derived from human periodontal ligament stem cells on periodontitis

Abstract Metformin has shown outstanding anti-inflammatory and osteogenic abilities. Mesenchymal stem cell-derived extracellular vesicles (EVs) reveal promising therapeutic potency by carrying various biomolecules. This study explored the effects of metformin on the therapeutic potential of EVs deri...

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Bibliographic Details
Main Authors: Mingli Xiang, Yulin Liu, Qiushuang Guo, Chengcheng Liao, Linlin Xiao, Meiling Xiang, Xiaoyan Guan, Jianguo Liu
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Scientific Reports
Subjects:
Metformin
Extracellular Vesicles
PDLSCs
Periodontitis
Alveolar bone resorption
Online Access:https://doi.org/10.1038/s41598-024-70688-w

Internet

https://doi.org/10.1038/s41598-024-70688-w

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