Role of the IL-33/ST2 Activation Pathway in the Development of the Hepatic Fibrosis Induced by <i>Schistosoma mansoni</i> Granulomas in Mice

Role of the IL-33/ST2 Activation Pathway in the Development of the Hepatic Fibrosis Induced by <i>Schistosoma mansoni</i> Granulomas in Mice

<i>Schistosoma mansoni</i> eggs retained in host tissues induce innate cytokine release, contributing to the induction of Type-2 immune responses and granuloma formation, important to restrain cytotoxic antigens, but leading to fibrosis. Interleukin(IL)-33 participates in experimental mo...

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Bibliographic Details
Main Authors: Laura Maggi, Genil Mororó Araújo Camelo, Izabella Chrystina Rocha, William Pereira Alves, João Marcelo Peixoto Moreira, Thiago Almeida Pereira, Wagner Luiz Tafuri, Élida Mara Leite Rabelo, Ary Correa, Roselene Ecco, Deborah Aparecida Negrão-Corrêa
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
<i>Schistosoma mansoni</i> infection
liver fibrosis
granuloma
collagen deposition
reticular fibres
IL-33/ST2 activation pathway
Online Access:https://www.mdpi.com/1422-0067/24/12/10237

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https://www.mdpi.com/1422-0067/24/12/10237

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