Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

Activity-dependent somatodendritic dopamine release in the substantia nigra autoinhibits the releasing neuron

Summary: Somatodendritic dopamine (DA) release from midbrain DA neurons activates D2 autoreceptors on these cells to regulate their activity. However, the source of autoregulatory DA remains controversial. Here, we test the hypothesis that D2 autoreceptors on a given DA neuron in the substantia nigr...

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Bibliographic Details
Main Authors: Takuya Hikima, Christian R. Lee, Paul Witkovsky, Julia Chesler, Konstantin Ichtchenko, Margaret E. Rice
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Cell Reports
Subjects:
autoreceptors
botulinum neurotoxin A metalloprotease
dendritic transmitter release
D2 dopamine receptors
exocytosis
GABAB receptors
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721002655

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http://www.sciencedirect.com/science/article/pii/S2211124721002655

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