Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

Pheophorbide a 17-diethylene glycol ester (XL-8), is a promising high-active derivative of known photosensitizer chlorin e6 used in photodynamic therapy. However, high lipophilicity and poor tumor accumulation limit XL-8 therapeutic application. We developed a novel XL-8 loaded with poly(D,L-lactide...

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Bibliographic Details
Main Authors: Mariia R. Mollaeva, Elena Nikolskaya, Veronika Beganovskaya, Maria Sokol, Margarita Chirkina, Sergey Obydennyi, Dmitry Belykh, Olga Startseva, Murad D. Mollaev, Nikita Yabbarov
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Antioxidants
Subjects:
photodynamic therapy
photosensitizer
cellular uptake
oxidative stress
reactive oxygen species
cell death
Online Access:https://www.mdpi.com/2076-3921/10/12/1985

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https://www.mdpi.com/2076-3921/10/12/1985

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