The Clinicopathological Significance of BiP/GRP-78 in Breast Cancer: A Meta-Analysis of Public Datasets and Immunohistochemical Detection

The Clinicopathological Significance of BiP/GRP-78 in Breast Cancer: A Meta-Analysis of Public Datasets and Immunohistochemical Detection

The endoplasmic reticulum chaperone BiP (also known as GRP-78 or HSPA5) maintains protein folding to allow cell proliferation and survival and has been implicated in carcinogenesis, tumor progression, and therapy resistance. BiP’s association with clinical factors and prognostic potential in breast...

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Bibliographic Details
Main Authors: Inês Direito, Daniela Gomes, Fátima Liliana Monteiro, Isa Carneiro, João Lobo, Rui Henrique, Carmen Jerónimo, Luisa Alejandra Helguero
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Current Oncology
Subjects:
unfolded protein response
breast cancer outcomes
therapy resistance
TCGA
immunohistochemistry
BiP/GRP-78
Online Access:https://www.mdpi.com/1718-7729/29/12/710

Internet

https://www.mdpi.com/1718-7729/29/12/710

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