Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles

Exploiting endocytosis for transfection of mRNA for cytoplasmatic delivery using cationic gold nanoparticles

IntroductionGene therapy holds promise to cure various diseases at the fundamental level. For that, efficient carriers are needed for successful gene delivery. Synthetic ‘non-viral’ vectors, as cationic polymers, are quickly gaining popularity as efficient vectors for transmitting genes. However, th...

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Bibliographic Details
Main Authors: Muriel F. Gustà, Michael J. Edel, Vivian A. Salazar, Belén Alvarez-Palomo, Manel Juan, Massimo Broggini, Giovanna Damia, Paolo Bigini, Alessandro Corbelli, Fabio Fiordaliso, Alexander Barbul, Rafi Korenstein, Neus G. Bastús, Víctor Puntes
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Immunology
Subjects:
gold nanoparticles
cationic
transfection
gene therapeutics
safety
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128582/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1128582/full

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