NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10

NDR1 mediates PD-L1 deubiquitination to promote prostate cancer immune escape via USP10

Abstract Prostate cancer (PCa) is one of the most common male genitourinary system malignancies. Despite the significant benefits of anti-PD-L1 immune checkpoint inhibitor therapy in other cancers, the reasons for its poor therapeutic efficacy in prostate cancer (PCa) remain unclear.NDR1 plays an im...

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Bibliographic Details
Main Authors: Meiling Fu, Jinxin Li, Zuodong Xuan, Zeyuan Zheng, Yankuo Liu, Zeyi Zhang, Jianzhong Zheng, Min Zhong, Bin Liu, Yifan Du, Lei Zhang, Huimin Sun
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Cell Communication and Signaling
Subjects:
Prostate cancer
NDR1/STK38, PD-L1
Immune escape
Immune checkpoint Blockade
Anti-PD-1 therapy
Online Access:https://doi.org/10.1186/s12964-024-01805-5

Internet

https://doi.org/10.1186/s12964-024-01805-5

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