Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2.

Long-term engraftment of human natural T regulatory cells in NOD/SCID IL2rγc(null) mice by expression of human IL-2.

Regulatory T cells are essential to maintain immune homeostasis and prevent autoimmunity. Therapy with in vitro expanded human nT(Regs) is being tested to prevent graft versus host disease, which is a major cause for morbidity and mortality associated with hematopoietic stem cell transplantation. Th...

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Bibliographic Details
Main Authors: Sojan Abraham, Rajendra Pahwa, Chunting Ye, Jang-Gi Choi, Savita Pahwa, Shashidhar Jaggaiahgari, Ashwin Raut, Shuiping Chen, N Manjunath, Premlata Shankar
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3525660?pdf=render

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