Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Sal003 alleviated intervertebral disc degeneration by inhibiting apoptosis and extracellular matrix degradation through suppressing endoplasmic reticulum stress pathway in rats

Apoptosis and extracellular matrix degradation of the nucleus pulposus are the main initiators of intervertebral disc degeneration (IVDD) and can be explained by endoplasmic reticulum (ER) stress. Thus, pharmacological therapy aimed at suppressing this pathway may be a promising approach for the man...

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Bibliographic Details
Main Authors: Yan Chen, Baixing Li, Yue Xu, Tangjun Zhou, Changqing Zhao, Jie Zhao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Pharmacology
Subjects:
ER stress pathway
Sal003
intervertebral disc degeneration
apoptosis
extracellular matrix degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1095307/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1095307/full

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