An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (<i>S</i>)-5-(<i>tert</i>-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (<i>S</i>)-5-(<i>tert</i>-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid

A catalytic and enantioselective preparation of the (<i>S</i>)-4-methyleneproline scaffold is described. The key reaction is a one-pot double allylic alkylation of an imine analogue of glycine in the presence of a chinchonidine-derived catalyst under phase transfer conditions. These 4-me...

Volledige beschrijving

Bibliografische gegevens
Hoofdauteurs: Blanca López, Martí Bartra, Ramon Berenguer, Xavier Ariza, Jordi Garcia, Roberto Gómez, Hèctor Torralvo
Formaat: Artikel
Taal:English
Gepubliceerd in: MDPI AG 2020-11-01
Reeks:Molecules
Onderwerpen:
phase-transfer catalysis
stereoselective synthesis
antiviral agent
proline analogue
Online toegang:https://www.mdpi.com/1420-3049/25/23/5644

Internet

https://www.mdpi.com/1420-3049/25/23/5644

Gelijkaardige items