An Enantioselective Approach to 4-Substituted Proline Scaffolds: Synthesis of (<i>S</i>)-5-(<i>tert</i>-Butoxy carbonyl)-5-azaspiro[2.4]heptane-6-carboxylic Acid
A catalytic and enantioselective preparation of the (<i>S</i>)-4-methyleneproline scaffold is described. The key reaction is a one-pot double allylic alkylation of an imine analogue of glycine in the presence of a chinchonidine-derived catalyst under phase transfer conditions. These 4-me...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-11-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/25/23/5644 |