Methylation Status of Exon IV of the Brain-Derived Neurotrophic Factor (BDNF)-Encoding Gene in Patients with Non-Diabetic Hyperglycaemia (NDH) before and after a Lifestyle Intervention

Methylation Status of Exon IV of the Brain-Derived Neurotrophic Factor (BDNF)-Encoding Gene in Patients with Non-Diabetic Hyperglycaemia (NDH) before and after a Lifestyle Intervention

BDNF signalling in hypothalamic neuronal circuits is thought to regulate mammalian food intake. In light of this, we investigated how a lifestyle intervention influenced serum levels and DNA methylation of BDNF gene in fat tissue and buffy coat of NDH individuals. In total, 20 participants underwent...

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Bibliographic Details
Main Authors: Helene A. Fachim, Nagaraj Malipatil, Kirk Siddals, Rachelle Donn, Gabriela Y. Cortés, Caroline F. Dalton, J. Martin Gibson, Adrian H. Heald
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Epigenomes
Subjects:
BDNF
non-diabetic hyperglycaemia
NDH
T2DM
lifestyle change
Online Access:https://www.mdpi.com/2075-4655/6/1/7

Internet

https://www.mdpi.com/2075-4655/6/1/7

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