Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial

Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial

Abstract Background Bilirubin neurotoxicity (BN) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty acids sufficiently to cause bilirubin displacement from...

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Bibliographic Details
Main Authors: Lindsay F. Holzapfel, Cody Arnold, Jon E. Tyson, Steven M. Shapiro, Eric W. Reynolds, Claudia Pedroza, Emily K. Stephens, Alan Kleinfeld, Andrew H. Huber, Matthew A. Rysavy, Maria del Mar Romero Lopez, Amir M. Khan
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Pediatrics
Subjects:
Bilirubin neurotoxicity
Extremely preterm infants
Lipid emulsions
Randomized controlled trial
Neurodevelopmental impairment
Brainstem auditory evoked responses
Online Access:https://doi.org/10.1186/s12887-023-04149-0

Internet

https://doi.org/10.1186/s12887-023-04149-0

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