A longitudinal study of cytochrome P450 2D6 (CYP2D6) activity during adolescence

Abstract CYP2D6 substrates are among the most highly prescribed medications in teenagers and also commonly associated with serious adverse events. To investigate the relative contributions of genetic variation, growth, and development on CYP2D6 activity during puberty, healthy children and adolescen...

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Bibliographic Details
Main Authors: J. Steven Leeder, Andrea Gaedigk, Krista J. Wright, Vincent S. Staggs, Sarah E. Soden, Yvonne S. Lin, Robin E. Pearce
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Clinical and Translational Science
Online Access:https://doi.org/10.1111/cts.13380