Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption

Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption

Introduction: Rapamycin is an immunosuppressor that acts by inhibiting the serine/threonine kinase mechanistic target of rapamycin complex 1. Therapeutic use of rapamycin is limited by its adverse effects. Proteinuria is an important marker of kidney damage and a risk factor for kidney diseases prog...

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Bibliographic Details
Main Authors: Rodrigo A. S. Peres, Diogo B. Peruchetti, Rodrigo P. Silva-Aguiar, Douglas E. Teixeira, Carlos P. Gomes, Christina M. Takiya, Ana Acacia S. Pinheiro, Celso Caruso-Neves
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Pharmacology
Subjects:
rapamycin
proximal tubule
megalin
protein reabsorption
proteinuria
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1194816/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1194816/full

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