Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity

Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity

Abstract Protein disulfide isomerase (PDI) is an endoplasmic reticulum (ER) enzyme that mediates the formation of disulfide bonds, and is also a therapeutic target for cancer treatment. Our previous studies found that PDI mediates apoptotic signaling by inducing mitochondrial dysfunction. Considerin...

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Bibliographic Details
Main Authors: Ruru Wang, Yajing Shang, Bin Chen, Feng Xu, Jie Zhang, Zhaoyang Zhang, Xipeng Zhao, Xiangbo Wan, An Xu, Lijun Wu, Guoping Zhao
Format: Article
Language:English
Published: Nature Publishing Group 2022-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05302-w

Internet

https://doi.org/10.1038/s41419-022-05302-w

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