Mechanical Tension Promotes the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway

Mechanical Tension Promotes the Osteogenic Differentiation of Rat Tendon-derived Stem Cells Through the Wnt5a/Wnt5b/JNK Signaling Pathway

Background/Aims: Tendinopathy is a common sports injury that is manifested by the heterotopic ossification of tendon tissue. Tendon stem cells (TSCs) are prone to osteogenic differentiation under excessive tension. The underlying mechanisms remain poorly understood. Methods: Uniaxial mechanical tens...

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Bibliographic Details
Main Authors: Xiangzhou Liu, Wan Chen, You Zhou, Kanglai Tang, Jiqiang Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-05-01
Series:Cellular Physiology and Biochemistry
Subjects:
Rat tendon-derived stem cells (rTDSCs)
Osteogenic differentiation
Wnt5a
Wnt5b
JNK
Online Access:http://www.karger.com/Article/FullText/430117

Internet

http://www.karger.com/Article/FullText/430117

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